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吴少华


研究员/ shwu123@126.com /微生物学

个人简历

1992.9-1996.7，中山大学化学系，应用化学专业，获学士学位；

1996. 9-2001. 12，中科院昆明植物研究所硕博连读，获博士学位；

2002. 1-2004. 11，古天乐太阳娱乐集团tyc493微生物研究所，助理研究员；

2002. 8-2003. 2，德国耶拿Hans-Knöll天然产物研究所，访问学者

2004. 12-2010. 11，古天乐太阳娱乐集团tyc493微生物研究所，副研究员

2010. 12-至今，古天乐太阳娱乐集团tyc493微生物研究所，研究员


主要研究方向

主要从事微生物学和天然产物化学研究。重点开展以下三个方面的研究：

1、植物内生菌资源及生物活性的研究：植物内生菌是微生物资源研究的热点之一，在农业和医药领域具有广阔的应用前景。从特色药用植物中分离和鉴定内生菌，进行内生菌资源的多样性研究，开展抗肿瘤、抗病毒、抗菌等多种生物活性筛选，发现有医用和农用潜力的活性菌株。

2、微生物活性天然产物的研究：综合运用微生物学、天然产物化学、药理学等多学科专业技术，开展不同生境来源的真菌和放线菌中活性次生代谢产物的分离、结构鉴定以及生理活性筛选，发现结构新颖的具有重要生理活性的化合物，致力于微生物天然药物的研究与开发。

3、植物内生菌与宿主之间关系密切，从内生菌的种群结构和次生代谢的角度探讨内生菌与宿主植物的相互作用。


教授课程

硕士生专业必修课《微生物资源与代谢产物化学》


主要论文

  1. Shou-Peng Zhang, Rong Huang, Fang-Fang Li, Hong-Xia Wei, Xiao-Wei Fang, Xiao-Song Xie, Dong-Guo Lin, Shao-Hua Wu*, Jian He*. Antiviral anthraquinones and azaphilones produced by an endophytic fungus Nigrospora sp. from Aconitum carmichaeli. Fitoterapia, 2016, 112, 85-89.

  2. Xiao-Song Xie, Xiao-Wei Fang, Rong Huang, Shou-Peng Zhang, Hong-Xia Wei, Shao-Hua Wu*. A new dimericanthraquinone from endophytic Talaromyces sp. YE3016. Natural Product Research, 2016, 30(15), 1706-1711.

  3. Rong Huang, Tang Wang, Xiao-Song Xie, Kai-Xia Ma, Xiao-Wei Fang, Shao-Hua Wu*. Secondary metabolites from an endophytic fungus Nigrospora sp. Chemistry of Natural Compounds, 2016, 52(4), 697-699.

  4. Huang Rong, Xie Xiao-Song, Xiao-Wei Fang, Ma Kai-Xia, Wu Shao-Hua*. Five new guaiane sesquiterpenes from the endophytic fungus Xylaria sp. YM 311647 of Azadirachta indica. Chemistry & Biodiversity, 2015, 12(8), 1281-1286.

  5. Huang Rong, Ma Kai-Xia, Xie Xiao-Song, Wang Tang, Wu Shao-Hua*. Secondary metabolites of an endophytic fungus Phomopsis sp., Chemistry of Natural Compounds, 2015, 51(2), 392-394.

  6. Wu Shao-Hua*, He Jian, Li Xiao-Nian, Huang Rong, Song Fei, Chen You-Wei, Miao Cui-Ping. Guaiane sesquiterpenes and isopimarane diterpenes from an endophytic fungus Xylaria sp. Phytochemistry, 2014, 105, 197-204.

  7. Song Fei, Wu Shao-Hua*, Zhai Ying-Zhe, Xuan Qi-Cun, Wang Tang. Secondary metabolites from the genus Xylaria and their bioactivities. Chemistry & Biodiversity, 2014, 11(5), 673- 694.

  8. Wang Tang, Jiang Yi, Ma Kai-Xia, Xie Xiao-Song, Wu Shao-Hua*. Two new butenolides produced by an actinomycete Streptomyces sp. Chemistry & Biodiversity, 2014, 11(6), 929-933.

  9. Ma Kai-Xia, Shen Xin-Tian, Huang Rong, Wang Tang, Xie Xiao-Song, Liu Shu-Wen, Wu Shao-Hua*, He Jian. Bioactive metabolites produced by the endophytic fungus Phomopsis sp. Natural Product Communications, 2014, 9(5), 669-670.

  10. Xuan Qi-Cun, Huang Rong, Chen You-Wei, Miao Cui-Ping, Ma Kai-Xia, Wang Tang, Wu Shao-Hua*. Cyclonerol derivatives from Trichoderma longibrachiatum YM311505. Natural Product Communications, 2014, 9(3), 313-314.

  11. Xuan Qi-Cun, Huang Rong, Miao Cui-Ping, Chen You-Wei, Zhai Ying-Zhe, Song Fei, Wang Tang, Wu Shao-Hua*. Secondary metabolites of endophytic fungus Trichoderma sp. YM 311505 of Azadirachta indica. Chemistry of Natural Compounds, 2014, 50(1), 139-141.

  12. Wu Shao-Hua*, Huang Rong, Miao Cui-Ping, Chen You-Wei. Two new steroids from an endophytic fungus Phomopsis sp. Chemistry & Biodiversity, 2013, 10(7), 1276-1283.

  13. Wu Shao-Hua*, Zhao Li-Xing, Chen You-Wei, Huang Rong, Miao Cui-Ping, Wang Jiao. Sesquiterpenoids from the endophytic fungus Trichoderma sp. PR-35 of Paeonia delavayi. Chemistry & Biodiversity, 2011, 8(9), 1717-1723.

  14. Wu Shao-Hua*, Chen You-Wei, Miao Cui-Ping. Secondary metabolites of endophytic fungus Xylaria sp. YC-10 of Azadirachta indica. Chemistry of Natural Compounds, 2011, 47(5), 858-861.

  15. Wu Shao-Hua*, Wu Da-Gang, Chen You-Wei. Chemical constituents and bioactivities of plants from the genus Paeonia. Chemistry & Biodiversity, 2010, 7(1), 90-104.

  16. Wu Shao-Hua*, Chen You-Wei, Shao Shi-Cheng, Wang Li-Dong, Yu Ying, Li Zhi-Ying, Yang Li-Yuan, Li Shao-Lan, Huang Rong. Two new solanapyrone analogues from the endophytic fungus Nigrospora sp. YB-141 of Azadirachta indica. Chemistry & Biodiversity, 2009, 6(1), 79-85.

  17. Wu Shao-Hua*, Chen You-Wei, Li Zhi-Ying, Yang Li-Yuan, Li Shao-Lan. Chemical constituents from the root bark of Paeonia delavayi. Chemistry of Natural Compounds, 2009, 45(4), 597-598.

  18. Wu Shao-Hua*, Shen Yue-Mao, Chen You-Wei, Li Zhi-Ying, Yang Li-Yuan, Li Shao-Lan. Chemical constituents from the stem bark of Trewia nudiflora. Chemistry of Natural Compounds, 2009, 45(4), 536-538.

  19. Wu Shao-Hua*, Chen You-Wei, Shao Shi-Cheng, Wang Li-Dong, Li Zhi-Ying, Yang Li-Yuan, Li Shao-Lan, Huang Rong. Ten-membered lactones from Phomopsis sp., an endophytic fungus of Azadirachta indica. Journal of Natural Products, 2008, 71(4), 731-734.

  20. Wu Shao-Hua, Chen You-Wei, Qin Sheng, Huang Rong. A new spiroketal from Aspergillus terreus, an endophytic fungus in Opuntia ficusindica Mill. Journal of Basic Microbiology, 2008, 48(2), 140-142.

  21. Wu Shao-Hua*, Chen You-Wei, Yang Li-Yuan, Li Shao-Lan, Li Zhi-Ying. A new ellagic acid glycoside from Paeonia delavayi. Fitoterapia, 2008, 79(6), 474-475.